ROS Producing and Scavenging Protein - DataBase (ROSBase)

ROS producing and scavenging proteins

In this database, we have collected information from literature and made it available in consolidated form. The dataset consists of information from various cell organelles where ROS is being produced or scavenged. In total 998 - ROS scavenging, 525 - ROS producing, 201 - ROS-indirect involvement, 770 - Both ROS producing and scavenging were identified.

Statistics for different categories in the DataBase

The database has total entries:2205 entries for both ROS producing and scavenging. The entries are as follows; PDB IDs: 6950; Total enetries: 2205; Protein:2205; UniProt IDs:2205; Genes: 2182; Organism: 262; Diseases: 219; Cell Organelles: 16.

Data Statistics based on 5 kingdom classification

The database classified based on 5kingdom classification; Animalia:1569; Plantae:359; Bacteria:334; Protista: 38; Fungi:197.

Data statistics based on Enzyme Class

There are total 7 enzyme class that classifies proteins based on their enzymatic activity; (1)Oxidoreductase: 692;(2)Transferases: 302;(3)Hydrolases: 186;(4)Lysases: 32;(5)Isomerases: 67;(6)Ligases: 12;(7)Translocases: 34;Non-Enzymatic Class: 1167

Data statistics based on Diseases/Disorders(anatomically)

There are a total of 143 protein entries that have been associated with recognised diseases. Each protein entry is expected to be associated with several diseases, resulting in a total of 235 disease entries. The database categorizes ROS-related proteins based on anatomy of diseases. The diseases have been classified anatomically(specific organ/tissue)into 14 distinct groups. The disease categories included Neurological Disorders (n=49), Genetic and Chromosomal Disorders (n=26), Autoinflammatory and Immunological Disorders (n=24), Metabolic and Endocrine Disorders (n=21), Musculoskeletal and Dermatological Disorders (n=19), Cancer and Tumour Syndromes (n=17), Mitochondrial Disorders (n=11), Hematological and Connective Tissue Disorders (n=11), Gastrointestinal and Digestive Disorders (n=10), Cardiovascular Disorders (n=8), Ophthalmological Disorders (n=7), Developmental Disorders (n=7), Renal and Urinary Disorders (n=6), Respiratory System Disorders (n=2).

About ROSBase

The ROS Producing and Scavenging Protein – DataBase (ROSBase) carries information about ROS related proteins. The database has a curated information about 18 proteins.

Contact Us

p20200004h@hyderabad.bits-pilani.ac.in / banerjee.debi@hyderabad.bits-pilani.ac.in
Birla Institute of Technology and Science Hyderabad Campus